Tachyplesin I is an antimicrobial peptide originally detected in the extract of hemocytes from the Japanese horseshoe crab. It inhibits the growth of both Gramnegative and -positive bacteria and forms a complex with bacterial lipopolysaccharides. These results suggest that this peptide belongs to the family of arthropodous peptide antibiotics. Furthermore this peptide has been shown to have antiviral activity against vesicular stomatitis virus, influenza A virus and HIV-1.
A.Morvan et al., J. Invertebr. Pathol., 69, 177 (1997) H.Tamamura et al., Biochem. Biophys. Res. Commun., 205, 1729 (1994) T.Katsu et al., Biol. Pharm. Bull., 16, 178 (1993) K.Kawano et al., J. Biol. Chem., 265, 15365 (1990) T.Miyata et al., J. Biochem., 106, 663 (1989)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H-Lys-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Arg-Gly-Ile-Cys-Tyr-Arg-Arg-Cys-Arg-NH₂ (Disulfide bonds between Cys³ and Cys¹⁶/Cys⁷ and Cys¹²)